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Ballota nigra (Black Horehound) Chemical Constituents & Activities

Family: Lamiaceae
Habit: perennial
Common Uses: cold, flu, nervousness (motion sickness)
Vaporization Temp: 212°F to 257°F (100°C to 125°C)
Notes: offensive odor

Chemical Constituents
Some Specific Chemical Activities

Chemical Constituents

Constituent Part ~ ppm
(+)-(E)-CAFFEOYL-L-MALIC-ACID shoot  
1-OCTEN-3-OL plant 4
13-HYDROXYBALLONIGRINOLIDE shoot  
7-ACETOXYMARRUBIIN plant  
7-ALPHA-ACETOXYMARRUBIIN shoot  
7-GLUCOSIDE shoot  
ALPHA-HUMULENE plant 8
ALPHA-PINENE plant 3
ALYSSONOSIDE shoot  
ANGOROSIDE-A shoot  
APIGENIN shoot  
ARENARIOSIDE shoot  
BALLONIGRIN plant  
BALLONIGRINE shoot  
BALLOTENOL plant, shoot  
BALLOTETROSIDE shoot  
BALLOTINONE plant, shoot  
BETA-PINENE plant 1
CAFFEIC-ACID leaf 2000
CAFFEOYL-MALIC-ACID shoot  
CARYOPHYLLENE plant 35
CHLOROGENIC-ACID plant  
CHOLINE plant  
COPAENE plant 19
DELTA-CADINENE plant 10
Essential Oil plant 300
FERULIC-ACID plant  
FORSYTHOSIDE-B shoot  
GALLIC-ACID plant  
GERMACRENE-D plant 127
LAVANDULIFOLIOSIDE shoot  
LINALOOL plant 3
MARRUBIIN plant  
PRELEOSIBIRIN plant, shoot  
RAFFINOSE root  
SABINENE plant 4
STACHYOSE root  
SUCROSE root  
TAGERETIN shoot  
TANNIN plant  
VERBASCOSE root  
VERBASCOSIDE shoot  
VICENIN-2 shoot  

Some Specific Chemical Activities


Activity
  • Specific Activity
    • chemical tested active
      • chemical tested inactive

  • Specific Activity
    • (0) = no tested for chemicals active

Antibacterial

Antioxidant (& Anticholesterol)

'The extracts of Ballota antalyense, Ballota macrodonta, Ballota glandulosissima, Ballota larendana, Ballota pseudodictamnus, Ballota nigra subsp. anatolica, Ballota saxatilis subsp. saxatilis, Ballota rotundifolia, and Ballota saxatilis subsp. brachyodonta exhibited remarkable anti-superoxide anion formation with IC(50) values from 0.50 to 0.87 mg/ml.' [Citoglu].

Sedative (Neuro)

 

References:

Citoglu, G. S., Coban, T., Sever, B., and Iscan, M. Antioxidant properties of Ballota species growing in Turkey. J Ethnopharmacol 2004;92(2-3):275-280. 15138012

Daels-Rakotoarison, D. A., Seidel, V., Gressier, B., Brunet, C., Tillequin, F., Bailleul, F., Luyckx, M., Dine, T., Cazin, M., and Cazin, J. C. Neurosedative and antioxidant activities of phenylpropanoids from ballota nigra. Arzneimittelforschung 2000;50(1):16-23. 10683711

Didry, N., Seidel, V., Dubreuil, L., Tillequin, F., and Bailleul, F. Isolation and antibacterial activity of phenylpropanoid derivatives from Ballota nigra. J Ethnopharmacol 11-1-1999;67(2):197-202. 10619384

Dr. Duke's Phytochemical and Ethnobotanical Databases; [Online Database] 21 February 2012.

Seidel, V., Bailleul, F., Libot, F., and Tillequin, F. A phenylpropanoid glycoside from Ballota nigra. Phytochemistry 1997;44(4):691-693. 9041717

Seidel, V., Verholle, M., Malard, Y., Tillequin, F., Fruchart, J. C., Duriez, P., Bailleul, F., and Teissier, E. Phenylpropanoids from Ballota nigra L. inhibit in vitro LDL peroxidation. Phytother Res 2000;14(2):93-98. 10685104

Studies in Natural Products Chemistry; Volume 33, Bioactive Natural Products (Part M); Atta-ur-Rahman/Editor

 

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